AcCl veya Ac2O Kullanılarak Bazı Norkantarimid Türevlerinin Moleküler Kararlılık, Sentez Mekanizması ve Oluşumunlarının İncelenmesi: Mekanizma Tabanlı Bir Çalışma

The aim in this study was first to explain, detail the conversion of diacetates over time into chlorinated monoacetates following ether cleavage with AcCl norcantharimide derivatives help NMR technique and second, verify theoretically computationally. Ether reactions N-methyl, N-benzyl, N-acetoxyethyl-substituted were performed Ac2O or presence H2SO4, mechanisms these elucidated detail. According 1H analyses aliquots from AcCl, trans-1,4-diacetates formed firstly. Upon continuation reaction, transformed trans-1,2-chloroacetates via an SN2' mechanism. Additionally, explanation further supported by soft theoretical physical calculations.